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drugs and medicine

Atorvastatin (Lipitor), Mechanism Of Action, Therapeutic Uses, Side effects

Atorvastatin (Lipitor) is effective in treating plasma LDL cholesterol and total cholesterol.

Mechanism Of Action:
Atorvastatin (Lipitor) competitively inhibit HMG co-enzyme A reductase, a rate limiting step in cholesterol synthesis. Reduce cholesterol synthesis results in compensatory increase in uptake of plasma cholesterol mediated by increase in number of LDL receptors. therefore LDL level in plasma reduces.

Therapeutic Uses:
Atorvastatin (Lipitor)reduces cholesterol levels in familial and non familial hypercholesterolemias.
Recent studies suggest that statins decreases osteoclast mediated bone resorption and may reduce osteoporosis moreover statins also decrease the incidence of some cancers

Adverse effects:
Myositis, rhabdomyolysis, anxiety, irritability, hepatotoxicity, and elevation in aminotransferasis.

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