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Acetaminophen is an over the counter drug, easily available without a prescription, but if taken especially if more than 12g is taken which is potentially fatal. The cause of death or the complication is usually the liver failure, which likely occurs if more than 250mg/kg of paracetamol is taken. If a patient arrives at the emergency department with paracetamol poisoning and has taken more than 200mg/kg or more than 10g of paracetamol then immediately resuscitate and start acetylcysteine which is the antidote for paracetamol poisoning. The dose of Acetylcysteine and Method of Administration Consider Oral acetylcysteine, if the patient is not confused and can easily tolerate the medicine orally, the injectable acetylcysteine may also be given by oral route. The oral dose is as follows. Oral Administration of Acetylcysteine The loading dose is 140mg/kg, after giving the loading dose, wait for four hours and after four hours give the maintenance dose, which is 70mg/kg. Repeat ...

  Different between acid and alkali poisoning. Acids Alkalies Acids precipitates proteins and cause their coagulation necrosis. The resultant coagulum limits further damage. Alkalies react with fats and sponify them. They also dissolve proteins. and Cause liqufactive necrosis and mostly cause more damage as compared to acids. Squamous epithelium of oral and esophagus is comparably more resistant to acids and the most commonly affected part is stomach antrum. On the other hand, squamous epithelium of pharynx and esophagus are most commonly affected in alkali toxicity. Most common complication of acid poisoning is perforation which mostly occurs on 3rd or 4th day. Most common complication of alkali poisoning is stricture formation and stricture mostly form after 2-4 weeks of injury but the stricture development depends on depth of burns. Presence of food in stomach decreases the corrosive effect of acids     Alkali burns tend to be more dangerous as co...