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Showing posts from December, 2016

Acromegaly - Cause - Diagnosis - Treatment - Dr. Adil Ramzan

Acromegaly is a condition which results due to excess of growth hormone. Growth hormone is secreted by the anterior lobe of the pituitary gland under the influence of growth hormone releasing hormone which is secreted by the hypothalamus. Causes of acromegaly.  In 90% of cases, the cause of growth hormone excess or acromegaly is Pituitary adenoma while other 10% causes include; Ectopic secretion of growth hormone or growth hormone releasing hormone by some tumour. Diagnosis of Acromegaly It is diagnosed by the clinical features, which include; large spade-like hands, frontal bossing, large jaw and gigantism. IGF 1 and growth hormone level are raised and MRI of the brain usually show pituitary adenoma.  Treatment of Acromegaly.  Any of the following regimens can be tried.  Surgery is the first line: Transsphenoidal resection of pituitary adenoma is the first line treatment, and usually cure the disease.  Dopamine agonists, for example, bromocriptine was the first lin