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MRCP Pearls

Cryoglobulinemia, Cryoglobulinemia Causes, Symptoms & Treatment

Cryoglobulinemia causes 

  1. Hep C
  2. Myeloma, 
  3. Waldenstrom’s macroglobulinemia, 
  4. SLE, 
  5. Rheumatoid arthritis, 
  6. Sjogren’s syndrome, 


Immunoglobulins precipitate when cooled under skin, ulcers, rashes, gangrene, Raynaud’s phenomenon. 


Plasma exchange, 


Treat the cause.

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