Serotonin-Nor epinephrine re-uptake inhibitors - Mechanism - Indications - Adverse/side effects - Antidepressants drugs

Serotonin-Norepinephrine Re-uptake Inhibitors – SNRI’s

SNRI’s inhibit the presynaptic reuptake of both serotonin and nor epinephrine. Those patients who don’t respond to SSRI,s may show response to SNRI,s

These drugs are similar in the action of Tricyclic antidepressants but differ in side effects profile. SNRI’s have fewer side effects and are better tolerated than TCA,s.

SNRI,s also reduces the backache and other neuropathic pains associated with depression. SSRI,s (selective serotonin reuptake inhibitors) have no effect on pain.

The following two drugs come into this category

Ø     Venlafaxine

Ø     Duloxetine

Indications:

ü     Depression

ü     Obsessive Compulsive Disorder (OCD) (Fluvoxamine)

ü     Panic disorder

ü     Generalize anxiety disorder

ü     Post traumatic Stress disorder

ü     Bulimia Nervosa (Fluoxetine)

Adverse Effects:

Venlafaxine side effects:

    Nausea

    Headache

    Sexual dysfunction

    Dizziness

    Insomnia

    Sedation

    Constipation

    Increase in blood pressure (in higher doses

    Increase in heart rate (in higher doses)

Duloxetine Adverse Effects:

    Nausea

    Dry mouth

    Constipation

    Diarrhoea

    Vomiting

    Insomnia

    Dizziness

    Somnolence

    Sweating

    Sexual dysfunction

    An increase in blood pressure and heart rate.