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Serotonin-Nor epinephrine re-uptake inhibitors - Mechanism - Indications - Adverse/side effects - Antidepressants drugs

Serotonin-Norepinephrine Re-uptake Inhibitors – SNRI’s

SNRI’s inhibit the presynaptic reuptake of both serotonin and nor epinephrine. Those patients who don’t respond to SSRI,s may show response to SNRI,s

These drugs are similar in the action of Tricyclic antidepressants but differ in side effects profile. SNRI’s have fewer side effects and are better tolerated than TCA,s.

SNRI,s also reduces the backache and other neuropathic pains associated with depression. SSRI,s (selective serotonin reuptake inhibitors) have no effect on pain.

The following two drugs come into this category

Ø     Venlafaxine
Ø     Duloxetine


ü     Obsessive Compulsive Disorder (OCD) (Fluvoxamine)
ü     Panic disorder
ü     Generalize anxiety disorder
ü     Post traumatic Stress disorder
ü     Bulimia Nervosa (Fluoxetine)

Adverse Effects:

Venlafaxine side effects:

*    Nausea
*    Headache
*    Sexual dysfunction
*    Dizziness
*    Insomnia
*    Sedation
*    Constipation
*    Increase in blood pressure (in higher doses
*    Increase in heart rate (in higher doses)

Duloxetine Adverse Effects:

*    Nausea
*    Dry mouth
*    Constipation
*    Diarrhoea
*    Vomiting
*    Insomnia
*    Dizziness
*    Somnolence
*    Sweating
*    Sexual dysfunction
*    An increase in blood pressure and heart rate.


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