Skip to main content

Serotonin (5HT) Receptors - Types/Subtypes of Serotonin (5HT) Receptors - Location of Serotonin (5HT) Receptors


Serotonin Receptors:

Serotonin is 5 hydroxytryptamine (5HT).  Four families of Serotonin receptors, comprising of 14 subtypes have so far been recognized.

Types of Serotonin (5HT) Receptors:


  1. 5-HT1
  2. 5-HT2
  3. 5-HT3
  4. 5-HT4-7

Location and effects of 5-HT receptors;

5-HT1 receptors:
These are present in brain. most important location is raphe nuclei of brain stem and hippocampus, the anti anxiety drug buprione acts as a partial agonis of 5-HT1A receptor. other locations include
  • substantia nigra
  • basal ganglia
  • cranial blood vessels ( cause contraction)
5HT1 receptors inhibit adenylyl cyclase and cause hyperpolarization of neurons and inhibit transmission.

5-HT2 Receptors:
There are three subtypes of 5-HT2 receptors, 
  • 5-HT2a, 
  • 5-HT2b, 
  • 5-HT2c,
these receptors are coupled to phospholipase C and act through generation of IP3 and GAG.
5HT2a is the most widely expressed postjunctional 5-HT receptor and located on vascular and viceral smooth muscles, platelets and cereberal neurones. 
it mediates vasoconstriction, intestinal , uterine and bronchial contraction.
5HT2b is present in rats
5HT2c is located on vascular endothelium and elicit vasodilation through Nitrous oxide release.

5-HT3 Receptor.
                        It is excitatory, it rapidly depolarizes nerve endings by opening the cation channel located within it. Responsible for pain, itch, coronary chemoreflex transmissions.

5-HT4-7 Receptors:
                        present in the smooth muscles of gut, neuronal plexus of gut wall, increase intestinal secretions and peristalsis.
Sponsored Links:
Labels:

Comments

Post a Comment

Post Your Reply and Give Your Opinion About the Post

Popular posts from this blog

Human Parasites, Types of Parasites, and Classification

Parasite: A parasite is a living organism which gets nutrition and protection from another organism where it lives. Parasites enter into the human body through mouth, skin and genitalia. In this article, we will generally discuss the types and classification of parasites. It is important from an academic point of view. Those parasites are harmful, which derives their nutrition and other benefits from the host and host get nothing in return but suffers from some injury. Types of Parasites Ecto-parasite: An ectoparasite lives outside on the surface of the body of the host. Endo-parasite: An endo-parasite lives inside the body of the host, it lives in the blood, tissues, body cavities, digestive tract or other organs. Temporary parasite: A temporary parasite visits its host for a short period of time. Permanent parasite: Permanent parasite lives its whole life in the host. Facultative parasite: A facultative parasite can live both independently and dependently. It lives in the...
Post a Comment
Read more.>>

How to taper off, wean off beta blocker, atenolol, Propranolol, Metoprolol

Beta blockers include, atenolol (Tenormin), propranolol (Inderal ) and metoprolol (Lopressor) and are used to treat high blood pressure, certain cardiac problems, migraine and few other conditions. People usually take atenolol, propranolol or metoprolol for many years as a treatment of high blood pressure or after having an episode of heart attack . Sometimes, it becomes necessary to withdraw these beta blockers due to their potential side effects that trouble the patients or sometimes doctor wants to change the drug and shift the patient to some other anti-hypertensive medicine. No matter whatever the cause is, whenever, a patient who has been using a beta blocker for a long period of time, and he needs to be stopped from further usage of that beta blocker, must not stop taking it. One should taper off the dose of a beta blocker. Now a question arises how to wean off or taper off a beta blocker? The method of tapering off beta blocker varies from individual to individual. Allow you...
Post a Comment
Read more.>>