Neo-Mercazole (Carbimazole) Dose Frequency - Divided vs Single Daily Dose.

Carbimazole (Neo-Mercazole), an antithyroid drug, which is used as a first line agent to treat hyperthyroidism, has a half-life of 5.3 hours. It can be given as a single daily dose or in divided doses.

Some physicians, recommend divided dose to minimize the gastrointestinal side effects, while the other physicians, recommend a single daily dose for better compliance.

Research studies showed that the efficacy of carbimazole (Neomercazole) when taken as a single dose per day or in divided doses, is similar or comparable. The single daily dose of Neomercazole is found to be superior to "Divided-dose" method as it is associated with better compliance. It may be difficult for patients to remember taking the divided doses. Sometimes, the patient may forget to take the evening dose. So a single daily dose is especially effective for those patients who find it difficult to remember the timings of divided dose.

Conclusion:
A single daily dose of Carbimazole is superior to a divided dose. As a single daily dose has similar efficacy as that of divided dose, and it is associated with better compliance of the patient to his medications.

Reference:

Single daily dose of Carbimazole in treatment of hyperthyroidism: Gupta SK 1992 Link: https://www.ncbi.nlm.nih.gov/pubmed/1302580

Comments

Cryoglobulinemia, Cryoglobulinemia Causes, Symptoms & Treatment

Cryoglobulinemia causes Hep C Myeloma, Waldenstrom’s macroglobulinemia, SLE, Rheumatoid arthritis, Sjogren’s syndrome, Symptoms, Immunoglobulins precipitate when cooled under skin, ulcers, rashes, gangrene, Raynaud’s phenomenon. Treatment. Plasma exchange, Chemotherapy, Treat the cause.

IELTS or OET - Reviews - Personal Experience - Which to Choose - IETLS vs OET

OET and IELTS both are used to assess the knowledge of English Language. The basic difference between the above two is this, IETLS is a more generalized English language assessment test, on the other hand, OET is profession specific. For example, if you are a doctor, the content of the test will be related to your occupation. Because of this, the OET is being chosen by many healthcare professional instead of IELTS. Both tests have the same sub-categories, that is listening, speaking, writing and reading. Lets us discuss the differences one by one. TEST OET IELTS OET Compared to IELTS is ………. (Author’s opinion) Speaking You will need to do two role plays. You will be given a situation and asked to counsel the patient about a disease and treatment or break the bad news. It has 3 parts, first is an introduction and general question, In the second part you will be provided with a topic to speak for 2 minutes. In the 3rd part, you will b...

MTI program Royal College of Physicians UK for International Doctors

MTI (Mutual Training Initiative) is a program which is sponsored by the Royal College of Physicians UK (all three colleges), you can work in the UK for a period of up to two years. It has the following requirements; 1. You should have MRCP part 1 passed (minimum requirement) 2. You must have got the required score in the IELTS or OET a. For IELTS the required score is minimum 7.0 in all subcategories (reading, listening, writing and speaking) and an overall score of 7.5. b. For OET the required score is grade B in all subcategories. 3. You must appear in an interview conducted by the Royal College of Physicians in your country and selected for the post OR you find a Job in the UK directly and inform Royal College of Physicians (London) that you have got the job by yourself and now you need RCP sponsorship for GMC registration. You do not need to pass PLAB or MRCP (all parts) to get t...

MedicoTips.Com

Search This Blog