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drugs and medicine

Nicotinic acid ( Niacin, Nicobid, Nicolar), Mechanism Of Action, Therapeutic Uses, Side effects


Nicotinic acid ( Niacin ) (brand names: Nicobid, Nicolar)
Mechanism Of Action
At higher doses, Nicotinic acid decrease lipolysis in the peripheral tissues, it also inhibit synthesis and esterification of fatty acids in liver. and therefore it decreases lipid level in blood.

Therapeutic uses:
At higher doses it is used in hyperlipidemia
at lower doses it used as vitamin and in the treatment of Pellagra

Advers Effects:
flushing, itching or burning sensation in skin can be decreased by taking aspirin 30 minutes before taking nicotinic acid because it is mediated by prostaglandins and histamine and aspirin inhibit prostaglandin synthesis. 
it also disturbs hepatic metabolism and may result in hyperglycemia, increased transaminases activity. It may cause GIT disturbances and peptic ulcer. Its renal side effects include elevated uric acid and macular edema.

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