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Treatment and Prevention Of Tuberculosis (TB)

Treatment Of Tuberculosis:

Isonizid, Rifampin, Ethambutol, and pyrazinamide are considered first line Drugs;

Isonizid, Rifampin Ethambutol and pyrazinamide are given in the first two months of the therapy.
after the first two months pyrazinamide and ethambutol are not given.
Only Isonizid and rifampin are given for next 4 - 8 months, depending upon the region.
In those areas of world where drug resistance is common, three drugs are give in continuation phase and the third drug which is used is ethambutol.

If in case TB is not cured by these drugs or Mycobacterium is resistant to one or more drugs than second line of therapy is used.
second line of therapy contain following medicines.

1. Capreomycin
2. Amikacin, and other aminoglycosides.
3. Ethionamide
4. Cycloserine
5. Para amino Silicylic acid.
6. Flouroquinolones (Used in MDR TB  but not yet approved by FDA yet)

Prevention of TB.

1. Immunization with BCG.
2. Public health measure for early detection ( tuberculin test, Xray chest)
3. Eradication of TB in cattle (test and slaughter
4. Pasteurization of milk
5. INH prophylaxis in highly risk persons

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