Difference between Crohn Disease and Ulcerative Colitis

Difference Between ulcerative colitis and Crohn disease is divided into three categories.

1. Macroscopic Differences
2. Microscopic Differences
3. Clinical Differences.

Macroscopic Difference

	Crohn Disease	Ulcerative Colitis
Bowel region Involved:	Ileum ± colon	Colon only.
Distribution Of lesions:	Skip lesions	diffuse
Stricture:	yes	rare
Wall appearance:	thick	thin

	Crohn Disease	Ulcerative Colitis
inflammation	transmural	Limited to mucosa
pseudopolyps	mild	marked
ulcers	deep	superficial
Lymphoid reaction	marked	moderate
fibrosis	marked	Mild to none
serositis	marked	Mild to none
granulomas	Yes (35 %)	no
Fistulae/sinuses	yes	no

	Crohn Disease	Ulcerative Colitis
Perianal fistula	yes	no
Fat/vitamin malabsorption	yes	no
Malignant potential	With colonic involvement	yes
Recurrence after surgery	common	no
Toxic megacolon	no	yes

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