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GIT

Difference between Crohn Disease and Ulcerative Colitis



Difference Between ulcerative colitis and crohn disease is divided into three categories.
  1. Macroscopic Differences
  2. Microscopic Differences
  3. Clinical Differences.
Macroscopic Difference
Crohn Disease
Ulcerative Colitis
Bowel region Involved:
Ileum ± colon
Colon only.
Distribution Of lesions:
Skip lesions
diffuse
Stricture:
yes
rare
Wall appearance:
thick
thin




Crohn Disease
Ulcerative Colitis
inflammation
transmural
Limited to mucosa
pseudopolyps
mild
marked
ulcers
deep
superficial
Lymphoid reaction
marked
moderate
fibrosis
marked
Mild to none
serositis
marked
Mild to none
granulomas
Yes (35 %)
no
Fistulae/sinuses
yes
no



Crohn Disease
Ulcerative Colitis
Perianal fistula
yes
no
Fat/vitamin malabsorption
yes
no
Malignant potential
With colonic involvement
yes
Recurrence after surgery
common
no
Toxic megacolon
no
yes
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