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Mebendazole and albendazole are benzimidazole carbamates that bind with high affinity to parasite free B-tubulin to inhibit its polymerization and microtubule assembly. These agents also irreversibly inhibit glucose uptake by nematodes; the resulting glycogen depletion and decreased ATP production immobilizes the intestinal parasite, which is then cleared from the GI tract. 
Indications:
Mebendazole is the drug of choice for the treatment of Trichuris trichuria (whipworm), Enterobius vermicularis (horse pinworm, pinworm), Ascaris lumbricoides (roundworm), as well as hookworm Ancylostoma duodenale and Necator americanus. For all these helminth mebendazole has success rates of at least 90 to 95%. It is also recommended for the treatment of Echinocossus granulosus and E. multilocularis infections
Mebendazole is available in Pakistan in various brand names. Each brand name along with manufacturing pharmaceutical industry is given below.

ALMEBALSON PHARMACEUTICALS
BELMENTICPARAMOUNT PHARMACEUTICALS
BELMENTICPARAMOUNT PHARMACEUTICAL
BELMENTICPARAMOUNT PHARMACEUTICALS

BENDAMOXUNEXO LABS (PVT) LTD

ERIZOLEEFROZE CHEMICAL INDUSTRIES (PVT) LTD.

GEOZOLEGEOFMAN PHARMACEUTICALS

GEOZOLEGEOFMAN PHARMACEUTICALS

G-WORMOLIVE LABORATORIES

HELMOXLAHORE CHEMICAL & PHARMACEUTICAL WORKS (PVT) LTD

MEBENSPENCER PHARMA
MEBENDAZOLEBENSON PHARAMCEUTICALS.
MEBENDAZOLEBENSON PHARAMCEUTICALS.

MEBEROWNCROWN PHARMACEUTICALS
MEBNAGENGENERA PHARMACEUTICALS
MEBNAGENGENERA PHARMACEUTICALS

MENAREXREX PHARMACEUTICALS PAKISTAN
MENDAZOLEVALOR PHARMACEUTICALS
MEZONILDR. RAZA PHARMA (PRIVATE) LIMITED

NEMAZOLEGLAXOSMITHKLINE
PANAMOXLIFE LINE PHARMACEUTICALS (PVT.) LTD.
PANAMOXLIFE LINE PHARMACEUTICALS (PVT.) LTD.
PAREXINNVOTEK PHARMACEUTICALS
PROVERMPHARMEDIC (PVT) LTD.
SPHINXLIBRA PHARMACEUTICALS (PVT) LTD

TAGAMEBTAGMA PHARMA (PVT) LTD.

VERMINADAMJEE PHARMACEUTICALS (PVT) LTD.

VERMOXJANSSEN-CILAG
WARTHSAYDON PHARMACEUTICAL INDUSTRIES (PVT) LTD.
WORCIDRAAZEE THERAPUTICS (PVT) LTD.
WORMAZOLESIZA INTERNATIONAL (PVT) LTD.
WORMDOXMEDICEENA PHARMA (PVT) LTD.
WORMDOXMEDICEENA PHARMA (PVT) LTD.
WORMIZOLEEPLA LABORATORIES (PVT) LTD.
ZENZOLJAWA PHARMACEUTICALS(PVT) LTD.
ZEWORMWILSHIRE LABORATORIES (PVT) LTD.
Dose and treatment Course
The same dosage schedule applies to children and adults. The tablet may be chewed, swallowed, or crushed and mixed with food.



Pinworm
(enterobiasis)
Whipworm
(trichuriasis)
Common
Roundworm
(ascariasis)
Hookworm
Dose1 tablet, once1 tablet morning and evening for 3 consecutive days.1 tablet morning and evening for 3 consecutive days.1 tablet morning and evening for 3 consecutive days.
If the patient is not cured three weeks after treatment, a second course of treatment is advised. No special procedures, such as fasting or purging, are required.
 
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